Total D-Forte Vit-D3 5.000 IU 28 Capsule

D-Forte 5,000 IU is an oral high-strength dietary supplement formulated with Cholecalciferol (Vitamin D3 - 5,000 IU / 125 mcg). As the physiologically active, bio-identical precursor to calcitriol (1,25-dihydroxyvitamin D3), it undergoes hepatic 25-hydroxylation via CYP2R1 to 25-hydroxyvitamin D, followed by renal alpha-hydroxylation via CYP27B1. Calcitriol binds nuclear Vitamin D receptors (VDR) across enterocytes and osteoblasts, upregulating active transcellular calcium transport (via TRPV6 and calbindin-D and modulating osteoclastogenesis to ensure optimal bone matrix turnover. This 5,000 IU intermediate therapeutic strength is formulated to correct mild-to-moderate hypovitaminosis D, support maintenance regimens post-loading therapy, and enhance musculoskeletal integrity, packaged in a box containing 28 capsules (4 blister strips of 7 capsules).

Key Benefits

• Corrects Suboptimal Vitamin D Levels: Effectively elevates circulating serum 25(OH)D concentrations in deficient or insufficient individuals back to the optimal physiological range.

• Enhances Calcium & Phosphate Absorption: Increases intestinal dietary calcium absorption from approximately 10–15% up to 30–40%, preserving normal serum calcium levels without triggering secondary hyperparathyroidism.

• Musculoskeletal Strength & Fall Prevention: Preserves bone mineral density (BMD), reduces osteomalacic aches and bone tenderness, and improves proximal muscle power and postural stability.

• Immune & Anti-Inflammatory Modulation: Regulates antimicrobial peptide expression (cathelicidin and defensins) and balances Th1/Th2/Th17 immune responses.

• Convenient Daily or Weekly Dosing Flexibility: Serves as a daily therapeutic dose for moderate deficiency or as an ongoing weekly/maintenance schedule under medical guidance.

Key Ingredients (per capsule)

• Vitamin D3 (Cholecalciferol - 5,000 IU / 125 mcg): Bioavailable fat-soluble vitamin derived from natural sources.

• Carrier & Capsule Excipients: Edible vegetable oil/triglycerides (facilitates dissolution and absorption of the lipophilic vitamin), gelatin, glycerin, purified water, and colorants.

Key Features

• Product Type: Oral High-Potency Vitamin D3 Supplement

• Indications: Treatment and prevention of Vitamin D insufficiency/deficiency, osteopenia, osteoporosis (as an adjunct to antiresorptive therapy), osteomalacia, and post-menopausal bone loss

• Lipid-vehicle formulation ensuring high gastrointestinal bioavailability

• Pack size: 28 capsules (4 blister strips × 7 capsules, providing a 4-week supply on a daily regimen)

How to Use

• Take 1 capsule daily (or as directed by your physician based on serum 25(OH)D levels).

• Swallow whole with water, preferably with or immediately after a meal containing dietary fats to optimize intestinal absorption.

• Monitor serum 25-hydroxyvitamin D levels periodically (typically after 8 to 12 weeks of continuous supplementation) to adjust dosing.

• Do not exceed the recommended dose without professional clinical supervision; contraindicated in patients with hypercalcemia, hypervitaminosis D, or severe nephrolithiasis.