{"product_id":"progesta-400mg-15-pessaries","title":"Progesta 400mg 15 pessaries","description":"\u003cp data-path-to-node=\"3\"\u003eProgesta 400 mg is a gynecological hormone formulation containing \u003cb data-path-to-node=\"3\" data-index-in-node=\"66\"\u003eMicronized Progesterone (400 mg)\u003c\/b\u003e, structurally identical to endogenous ovarian and placental human progesterone. Administered vaginally or rectally, it circumvents extensive first-pass hepatic degradation, achieving sustained local endometrial tissue concentrations. Progesterone promotes the complete secretory differentiation of an estrogen-primed endometrium, facilitates blastocyst implantation, and maintains myometrial quiescence by suppressing oxytocin receptors and downregulating prostaglandin synthesis. It is formulated to provide intensive luteal support during Assisted Reproductive Technology (ART) cycles and to manage threatened or recurrent pregnancy loss attributed to luteal phase insufficiency, packaged in blister strips containing \u003cb data-path-to-node=\"3\" data-index-in-node=\"819\"\u003e15 pessaries\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp data-path-to-node=\"3\"\u003e \u003c\/p\u003e\n\u003ch4 data-path-to-node=\"4\"\u003eKey Benefits\u003c\/h4\u003e\n\u003cul data-path-to-node=\"5\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"5,0,0\"\u003e\u003cb data-path-to-node=\"5,0,0\" data-index-in-node=\"0\"\u003eDirect Endometrial Delivery:\u003c\/b\u003e Vaginal administration utilizes the \"first uterine pass effect,\" concentrating progesterone directly in target uterine tissues with minimal systemic fluctuations.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"5,1,0\"\u003e\u003cb data-path-to-node=\"5,1,0\" data-index-in-node=\"0\"\u003eLuteal Phase Support in ART:\u003c\/b\u003e Prepares and maintains the receptive secretory endometrium needed for embryo implantation during IVF\/ICSI protocols.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"5,2,0\"\u003e\u003cb data-path-to-node=\"5,2,0\" data-index-in-node=\"0\"\u003eUterine Quiescence \u0026amp; Pregnancy Maintenance:\u003c\/b\u003e Inhibits spontaneous uterine contractions by downregulating myometrial gap junctions and prostaglandin production, managing recurrent or threatened miscarriage risks.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"5,3,0\"\u003e\u003cb data-path-to-node=\"5,3,0\" data-index-in-node=\"0\"\u003eDual Administration Routes:\u003c\/b\u003e Suitable for deep vaginal insertion, or rectal insertion in cases of vaginal bleeding, active localized infection, or following recent delivery.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"5,4,0\"\u003e\u003cb data-path-to-node=\"5,4,0\" data-index-in-node=\"0\"\u003eAvoids Hepatic First-Pass Side Effects:\u003c\/b\u003e Significantly reduces daytime sedation, somnolence, dizziness, and hepatic strain compared to conventional oral progesterone preparations.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch4 data-path-to-node=\"6\"\u003eKey Ingredients (per pessary)\u003c\/h4\u003e\n\u003cul data-path-to-node=\"7\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"7,0,0\"\u003e\u003cb data-path-to-node=\"7,0,0\" data-index-in-node=\"0\"\u003eMicronized Progesterone (400 mg):\u003c\/b\u003e Bio-identical, naturally derived micronized steroid hormone.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"7,1,0\"\u003e\u003cb data-path-to-node=\"7,1,0\" data-index-in-node=\"0\"\u003eSuppository Base:\u003c\/b\u003e Hard fat \/ semi-synthetic glycerides formulated to melt smoothly at body temperature without mucosal irritation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch4 data-path-to-node=\"8\"\u003eKey Features\u003c\/h4\u003e\n\u003cul data-path-to-node=\"9\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"9,0,0\"\u003e\u003cb data-path-to-node=\"9,0,0\" data-index-in-node=\"0\"\u003eProduct Type:\u003c\/b\u003e Vaginal \/ Rectal Pessaries (Suppositories) - Prescription Endocrine Medication\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"9,1,0\"\u003e\u003cb data-path-to-node=\"9,1,0\" data-index-in-node=\"0\"\u003eIndications:\u003c\/b\u003e Luteal phase support in assisted reproduction (IVF\/ICSI), threatened miscarriage, recurrent pregnancy loss due to documented luteal insufficiency, and severe premenstrual syndrome (PMS) \/ postpartum depression\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"9,2,0\"\u003eHigh-dose 400 mg strength optimized for intensive reproductive regimens\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"9,3,0\"\u003ePack size: 15 pessaries (suppositories)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch4 data-path-to-node=\"10\"\u003eHow to Use\u003c\/h4\u003e\n\u003cul data-path-to-node=\"11\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"11,0,0\"\u003e\u003cb data-path-to-node=\"11,0,0\" data-index-in-node=\"0\"\u003eVaginal Administration:\u003c\/b\u003e Insert \u003cb data-path-to-node=\"11,0,0\" data-index-in-node=\"31\"\u003e1 pessary (400 mg) deeply into the vagina once or twice daily\u003c\/b\u003e (morning and\/or at bedtime) as directed by a specialist, preferably while lying down.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"11,1,0\"\u003e\u003cb data-path-to-node=\"11,1,0\" data-index-in-node=\"0\"\u003eRectal Administration:\u003c\/b\u003e Insert into the rectum if experiencing heavy vaginal bleeding, localized vaginal infection, or using barrier contraception.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"11,2,0\"\u003eUse panty liners to protect undergarments from melting excipient residue; do not use tampons during treatment.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"11,3,0\"\u003eComplete the full prescribed course (in ART protocols, commonly continued through weeks 10 to 12 of confirmed gestation); do not stop abruptly without medical supervision.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Generic","offers":[{"title":"Default Title","offer_id":52192103661863,"sku":null,"price":3.38,"currency_code":"KWD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0708\/5044\/5607\/files\/Progesta_400mg_15_pessaries.jpg?v=1790626027","url":"https:\/\/thetrustpharmacy.com\/en\/products\/progesta-400mg-15-pessaries","provider":"Trust Pharmacy","version":"1.0","type":"link"}