Progesta 400mg 15 pessaries

Progesta 400 mg is a gynecological hormone formulation containing Micronized Progesterone (400 mg), structurally identical to endogenous ovarian and placental human progesterone. Administered vaginally or rectally, it circumvents extensive first-pass hepatic degradation, achieving sustained local endometrial tissue concentrations. Progesterone promotes the complete secretory differentiation of an estrogen-primed endometrium, facilitates blastocyst implantation, and maintains myometrial quiescence by suppressing oxytocin receptors and downregulating prostaglandin synthesis. It is formulated to provide intensive luteal support during Assisted Reproductive Technology (ART) cycles and to manage threatened or recurrent pregnancy loss attributed to luteal phase insufficiency, packaged in blister strips containing 15 pessaries.

Key Benefits

• Direct Endometrial Delivery: Vaginal administration utilizes the "first uterine pass effect," concentrating progesterone directly in target uterine tissues with minimal systemic fluctuations.

• Luteal Phase Support in ART: Prepares and maintains the receptive secretory endometrium needed for embryo implantation during IVF/ICSI protocols.

• Uterine Quiescence & Pregnancy Maintenance: Inhibits spontaneous uterine contractions by downregulating myometrial gap junctions and prostaglandin production, managing recurrent or threatened miscarriage risks.

• Dual Administration Routes: Suitable for deep vaginal insertion, or rectal insertion in cases of vaginal bleeding, active localized infection, or following recent delivery.

• Avoids Hepatic First-Pass Side Effects: Significantly reduces daytime sedation, somnolence, dizziness, and hepatic strain compared to conventional oral progesterone preparations.

Key Ingredients (per pessary)

• Micronized Progesterone (400 mg): Bio-identical, naturally derived micronized steroid hormone.

• Suppository Base: Hard fat / semi-synthetic glycerides formulated to melt smoothly at body temperature without mucosal irritation.

Key Features

• Product Type: Vaginal / Rectal Pessaries (Suppositories) - Prescription Endocrine Medication

• Indications: Luteal phase support in assisted reproduction (IVF/ICSI), threatened miscarriage, recurrent pregnancy loss due to documented luteal insufficiency, and severe premenstrual syndrome (PMS) / postpartum depression

• High-dose 400 mg strength optimized for intensive reproductive regimens

• Pack size: 15 pessaries (suppositories)

How to Use

• Vaginal Administration: Insert 1 pessary (400 mg) deeply into the vagina once or twice daily (morning and/or at bedtime) as directed by a specialist, preferably while lying down.

• Rectal Administration: Insert into the rectum if experiencing heavy vaginal bleeding, localized vaginal infection, or using barrier contraception.

• Use panty liners to protect undergarments from melting excipient residue; do not use tampons during treatment.

• Complete the full prescribed course (in ART protocols, commonly continued through weeks 10 to 12 of confirmed gestation); do not stop abruptly without medical supervision.