{"product_id":"ondavell-5-ampoules","title":"Ondavell 5 ampoules","description":"\u003cp data-path-to-node=\"3\"\u003eOndavell is a sterile injectable antiemetic solution formulated with \u003cb data-path-to-node=\"3\" data-index-in-node=\"69\"\u003eOndansetron (as Ondansetron Hydrochloride Dihydrate)\u003c\/b\u003e, available in two standard therapeutic presentations: \u003cb data-path-to-node=\"3\" data-index-in-node=\"176\"\u003e4 mg \/ 2 ml\u003c\/b\u003e and \u003cb data-path-to-node=\"3\" data-index-in-node=\"192\"\u003e8 mg \/ 4 ml\u003c\/b\u003e (both delivering a standardized concentration of 2 mg\/ml). As a potent, highly selective competitive antagonist of serotonin type 3 receptors, ondansetron acts simultaneously at peripheral and central neurological sites. Cytotoxic chemotherapy, ionizing abdominal radiotherapy, and surgical tissue handling trigger the massive release of serotonin (5-hydroxytryptamine) from enterochromaffin cells of the intestinal mucosa. This released serotonin activates visceral vagal afferent fibers, transmitting emetogenic signals to the solitary tract nucleus and triggering the central vomiting reflex via the chemoreceptor trigger zone (CTZ) in the area postrema. By selectively blocking these receptors without exhibiting dopamine-receptor antagonism, Ondavell effectively suppresses both peripheral emetic initiation and central emetic amplification without inducing extrapyramidal side effects or sedation. It is packaged in boxes containing \u003cb data-path-to-node=\"3\" data-index-in-node=\"1187\"\u003e5 sterile glass ampoules\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp data-path-to-node=\"3\"\u003e \u003c\/p\u003e\n\u003ch4 data-path-to-node=\"4\"\u003eKey Benefits\u003c\/h4\u003e\n\u003cul data-path-to-node=\"5\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"5,0,0\"\u003e\u003cb data-path-to-node=\"5,0,0\" data-index-in-node=\"0\"\u003eTargeted Emetic Suppression:\u003c\/b\u003e Provides highly selective \u003cspan class=\"math-inline\" data-math=\"5\\text{-HT}_3\" data-index-in-node=\"55\"\u003e5HT3 \u003c\/span\u003ereceptor blockade, rapidly controlling acute emetic episodes without antidopaminergic or sedative liabilities.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"5,1,0\"\u003e\u003cb data-path-to-node=\"5,1,0\" data-index-in-node=\"0\"\u003eNo Extrapyramidal Effects:\u003c\/b\u003e Unlike metoclopramide or phenothiazines, it does not block dopamine \u003cspan class=\"math-inline\" data-math=\"D_2\" data-index-in-node=\"95\"\u003eD2\u003c\/span\u003e receptors, eliminating the risk of acute dystonia, akathisia, or parkinsonian symptoms.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"5,2,0\"\u003e\u003cb data-path-to-node=\"5,2,0\" data-index-in-node=\"0\"\u003eDual Peripheral \u0026amp; Central Mechanism:\u003c\/b\u003e Simultaneously dampens visceral vagal signaling from the gut and blunts emetic signal integration in the area postrema \/ CTZ.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"5,3,0\"\u003e\u003cb data-path-to-node=\"5,3,0\" data-index-in-node=\"0\"\u003eFlexible Dual Parenteral Routes:\u003c\/b\u003e Suitable for rapid slow intravenous (IV) bolus, dilution for IV piggyback infusion, or deep intramuscular (IM) injection.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"5,4,0\"\u003e\u003cb data-path-to-node=\"5,4,0\" data-index-in-node=\"0\"\u003eRapid Clinical Onset:\u003c\/b\u003e Achieves immediate systemic therapeutic concentrations following IV administration, delivering rapid antiemetic control in post-operative or oncological settings.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch4 data-path-to-node=\"6\"\u003eKey Ingredients \u0026amp; Compositions\u003c\/h4\u003e\n\u003cul data-path-to-node=\"7\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"7,0,0\"\u003e\u003cb data-path-to-node=\"7,0,0\" data-index-in-node=\"0\"\u003eActive Ingredient:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"7,0,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"7,0,1,0,0\"\u003e\u003cb data-path-to-node=\"7,0,1,0,0\" data-index-in-node=\"0\"\u003eOndavell 4 mg:\u003c\/b\u003e Ondansetron Hydrochloride Dihydrate equivalent to \u003cb data-path-to-node=\"7,0,1,0,0\" data-index-in-node=\"65\"\u003e4 mg Ondansetron base per 2 ml ampoule\u003c\/b\u003e (2 mg\/ml).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"7,0,1,1,0\"\u003e\u003cb data-path-to-node=\"7,0,1,1,0\" data-index-in-node=\"0\"\u003eOndavell 8 mg:\u003c\/b\u003e Ondansetron Hydrochloride Dihydrate equivalent to \u003cb data-path-to-node=\"7,0,1,1,0\" data-index-in-node=\"65\"\u003e8 mg Ondansetron base per 4 ml ampoule\u003c\/b\u003e (2 mg\/ml).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"7,1,0\"\u003e\u003cb data-path-to-node=\"7,1,0\" data-index-in-node=\"0\"\u003eAqueous Vehicle \u0026amp; Excipients:\u003c\/b\u003e Sodium chloride (isotonicity agent), citric acid monohydrate and sodium citrate dihydrate (buffering system to physiological pH 3.3–4.0), and water for injections.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"7,2,0\"\u003e\u003ci data-path-to-node=\"7,2,0\" data-index-in-node=\"0\"\u003eSterile, preservative-free, apyrogenic solution.\u003c\/i\u003e\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch4 data-path-to-node=\"8\"\u003eKey Features\u003c\/h4\u003e\n\u003cul data-path-to-node=\"9\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"9,0,0\"\u003e\u003cb data-path-to-node=\"9,0,0\" data-index-in-node=\"0\"\u003eProduct Type:\u003c\/b\u003e Sterile Parenteral Solution for IV Injection \/ IV Infusion \/ IM Injection (Hospital \u0026amp; Clinical Prescription Medication)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"9,1,0\"\u003e\u003cb data-path-to-node=\"9,1,0\" data-index-in-node=\"0\"\u003eIndications:\u003c\/b\u003e\u003c\/p\u003e\n\u003cul data-path-to-node=\"9,1,1\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"9,1,1,0,0\"\u003ePrevention and treatment of chemotherapy-induced nausea and vomiting (CINV) in moderately to highly emetogenic regimens\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"9,1,1,1,0\"\u003ePrevention and treatment of radiotherapy-induced nausea and vomiting (RINV)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"9,1,1,2,0\"\u003ePrevention and treatment of post-operative nausea and vomiting (PONV) in adults and pediatric patients\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"9,2,0\"\u003eFree from sedative, anticholinergic, and dopaminergic side effects\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"9,3,0\"\u003ePresentation: 5 sterile glass ampoules per pack (2 ml or 4 ml ampoules)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e","brand":"Generic","offers":[{"title":"4 mg \/ 2ml","offer_id":52231870611751,"sku":null,"price":5.6,"currency_code":"KWD","in_stock":true},{"title":"8 mg \/ 4ml","offer_id":52231870644519,"sku":null,"price":2.85,"currency_code":"KWD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0708\/5044\/5607\/files\/Ondavell_4mg_5_ampoules.jpg?v=1791131900","url":"https:\/\/thetrustpharmacy.com\/en\/products\/ondavell-5-ampoules","provider":"Trust Pharmacy","version":"1.0","type":"link"}