Methycobal 500 Mcg 100 Tablets

Methycobal 500 mcg (manufactured by Eisai) is an oral neurotrophic prescription formulation containing Mecobalamin (500 mcg), the biologically pre-activated methylcobalamin coenzyme form of Vitamin B12. Unlike generic cyanocobalamin, mecobalamin bypasses initial hepatic biotransformation and preferentially distributes to peripheral nervous tissue and neuronal organelles. It acts as an essential co-factor in transmethylation reactions, drives the synthesis of lecithin (phosphatidylcholine) for myelin sheath assembly, stimulates nucleic acid and protein synthesis in axonal structures, and repairs delayed action potential conduction velocities. This specific packaging is an extended therapeutic economy pack containing 100 film/sugar-coated tablets (10 blister strips of 10 tablets) protected against photodegradation, designed for chronic neuropathic management courses.

Key Benefits

• Direct Neuronal Bioavailability: Pre-activated methylation-ready form that delivers immediate cofactor activity without requiring metabolic conversion by the liver or kidneys.

• Myelin Sheath Repair & Neuroregeneration: Up-regulates methionine synthase activity, accelerating phospholipid (lecithin) turnover required to regenerate damaged myelin sheaths.

• Restoration of Conduction Velocity: Normalizes delayed nerve impulses and action potentials across sensory and motor fibers, relieving peripheral numbness, burning paresthesias, and tingling.

• Axonal Protein Transport: Enhances ribosomal RNA and protein synthesis within neuronal perikarya, facilitating active axonal transport along damaged nerve tracts.

• Erythroblast Maturation Support: Supports nucleic acid synthesis in bone marrow stem cells, preventing and correcting megaloblastic anemia caused by B12 deficiency.

• Long-Term Treatment Pack: The 100-tablet size ensures uninterrupted therapy throughout the recommended 1 to 3-month course for peripheral nerve regeneration.

Key Ingredients (per tablet)

• Mecobalamin / Methylcobalamin (500 mcg / 0.5 mg): Naturally occurring, methylation-competent cobalamin coenzyme.

• Pharmaceutical Excipients: Lactose monohydrate, corn starch, microcrystalline cellulose, magnesium stearate, light-protective coating matrix (sucrose/hypromellose film), and colorants.

Key Features

• Product Type: Oral Neurotrophic Vitamin B12 Formulation

• Manufacturer: Eisai Co., Ltd.

• Indications: Diabetic peripheral neuropathy, alcoholic polyneuropathy, drug-induced neuropathies (e.g., chemotherapy, isoniazid), intercostal neuralgia, Bell’s palsy (facial nerve paresis), entrapment neuropathies (carpal tunnel syndrome), and megaloblastic anemia due to Vitamin B12 deficiency

• High therapeutic safety index with rapid renal excretion of any water-soluble excess

• Pack size: 100 tablets (10 blister strips × 10 tablets)

How to Use

• Adult Dosage: 1 tablet (500 mcg) taken orally 3 times daily (total daily dose: 1,500 mcg).

• Swallow whole with water, with or without meals.

• Adjust duration and dosage based on clinical response and physician recommendation; chronic diabetic neuropathy typically requires at least 4 to 12 weeks of continuous adherence.

• Keep tablets in their protective blister packaging away from direct light and moisture until ingestion.