{"product_id":"diamicron-mr-60-mg-modified-release-30-tablets","title":"Diamicron MR 60 mg Modified-Release 30 Tablets","description":"\u003cp data-path-to-node=\"3\"\u003eDiamicron MR 60 mg is an oral modified-release hypoglycemic medication formulated with \u003cb data-path-to-node=\"3\" data-index-in-node=\"87\"\u003eGliclazide (60 mg)\u003c\/b\u003e, a second-generation sulfonylurea with an endocyclic N-containing azabicyclo-octyl heterocyclic ring. Gliclazide acts primarily as a pancreatic secretagogue by binding selectively with high affinity to the sulfonylurea receptor-1 (SUR1) subunits of ATP-sensitive potassium channels (K-ATP) located on the plasma membrane of pancreatic beta-cells. This binding closes the K-ATP channels, inducing cell membrane depolarization, opening voltage-dependent L-type calcium channels, and triggering regulated calcium influx. The elevation of intracellular free calcium promotes the exocytosis of insulin-containing secretory granules, partially restoring the physiological early first-phase insulin secretion peak and augmenting the second phase in response to ambient glucose concentrations. Uniquely among sulfonylureas, gliclazide exhibits independent hemovascular protective properties, attenuating microvascular thrombosis by inhibiting platelet aggregation and adhesion and restoring physiological fibrinolytic activity via tissue-type plasminogen activator (t-PA) upregulation. Formulated in a hydrophilic hypromellose matrix, each breakable modified-release tablet ensures continuous, linear drug release matching the 24-hour circadian glycemic profile, packaged in blister strips containing \u003cb data-path-to-node=\"3\" data-index-in-node=\"1399\"\u003e30 breakable modified-release tablets\u003c\/b\u003e.\u003c\/p\u003e\n\u003cp data-path-to-node=\"3\"\u003e \u003c\/p\u003e\n\u003ch4 data-path-to-node=\"4\"\u003eKey Benefits\u003c\/h4\u003e\n\u003cul data-path-to-node=\"5\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"5,0,0\"\u003e\u003cb data-path-to-node=\"5,0,0\" data-index-in-node=\"0\"\u003eGlycemic Control:\u003c\/b\u003e Enhances endogenous insulin release, significantly lowering fasting blood glucose (FBG), postprandial glucose (PPG), and glycosylated hemoglobin (HbA1c).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"5,1,0\"\u003e\u003cb data-path-to-node=\"5,1,0\" data-index-in-node=\"0\"\u003eRestoration of First-Phase Insulin Secretion:\u003c\/b\u003e Improves the rapid initial insulin secretory surge typically blunted in early type 2 diabetes, mitigating postprandial glycemic excursions.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"5,2,0\"\u003e\u003cb data-path-to-node=\"5,2,0\" data-index-in-node=\"0\"\u003eHemovascular \u0026amp; Endothelial Protection:\u003c\/b\u003e Counteracts microvascular complications by reducing platelet hyper-reactivity, lowering platelet-activating markers, and neutralizing free radicals via its azabicyclo-octyl moiety.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"5,3,0\"\u003e\u003cb data-path-to-node=\"5,3,0\" data-index-in-node=\"0\"\u003eLower Hypoglycemia Risk:\u003c\/b\u003e Exhibits reversible, selective pancreatic SUR1 binding without non-specific interaction with cardiac (SUR2A) or vascular smooth muscle (SUR2B) channels, carrying a lower incidence of severe hypoglycemia compared to glibenclamide.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"5,4,0\"\u003e\u003cb data-path-to-node=\"5,4,0\" data-index-in-node=\"0\"\u003e24-Hour Circadian Coverage:\u003c\/b\u003e Hydrophilic matrix guarantees sustained, steady systemic absorption with a single morning dose, aligning with the daily pharmacokinetic requirement.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch4 data-path-to-node=\"6\"\u003eKey Ingredients (per tablet)\u003c\/h4\u003e\n\u003cul data-path-to-node=\"7\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"7,0,0\"\u003e\u003cb data-path-to-node=\"7,0,0\" data-index-in-node=\"0\"\u003eGliclazide (60 mg):\u003c\/b\u003e Active second-generation sulfonylurea oral antidiabetic agent.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"7,1,0\"\u003e\u003cb data-path-to-node=\"7,1,0\" data-index-in-node=\"0\"\u003eModified-Release Matrix \u0026amp; Excipients:\u003c\/b\u003e Hypromellose (hydroxypropyl methylcellulose 100 and 4000), calcium hydrogen phosphate dihydrate, maltodextrin, colloidal anhydrous silica, and magnesium stearate.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch4 data-path-to-node=\"8\"\u003eKey Features\u003c\/h4\u003e\n\u003cul data-path-to-node=\"9\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"9,0,0\"\u003e\u003cb data-path-to-node=\"9,0,0\" data-index-in-node=\"0\"\u003eProduct Type:\u003c\/b\u003e Oral Hypoglycemic Agent \/ Modified-Release Sulfonylurea (Prescription Antidiabetic Medication)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"9,1,0\"\u003e\u003cb data-path-to-node=\"9,1,0\" data-index-in-node=\"0\"\u003eIndications:\u003c\/b\u003e Non-insulin-dependent Type 2 Diabetes Mellitus (T2DM) in adults when dietary measures, physical exercise, and weight loss alone are insufficient\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"9,2,0\"\u003eHydrophilic hypromellose sustained-release matrix\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"9,3,0\"\u003eBreakable oblong tablet with score line (allows splitting into two equal 30 mg halves)\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"9,4,0\"\u003ePack size: 30 modified-release scored tablets\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003cp\u003e \u003c\/p\u003e\n\u003ch4 data-path-to-node=\"10\"\u003eHow to Use\u003c\/h4\u003e\n\u003cul data-path-to-node=\"11\"\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"11,0,0\"\u003eTake orally as a \u003cb data-path-to-node=\"11,0,0\" data-index-in-node=\"17\"\u003esingle daily dose at breakfast time\u003c\/b\u003e (or with the morning first meal).\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"11,1,0\"\u003eStandard maintenance dosing ranges from \u003cb data-path-to-node=\"11,1,0\" data-index-in-node=\"40\"\u003e30 mg to 120 mg once daily\u003c\/b\u003e (half a tablet to two tablets once daily), titrated gradually based on individual blood glucose and HbA1c targets.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"11,2,0\"\u003eSwallow the tablet (or halved tablet) whole with a full glass of water; \u003cb data-path-to-node=\"11,2,0\" data-index-in-node=\"72\"\u003edo not chew or crush\u003c\/b\u003e the tablet matrix, as this destroys the modified-release delivery mechanism.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"11,3,0\"\u003eRegular daily meals containing carbohydrates must be consumed following ingestion to prevent hypoglycemia.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003cli\u003e\n\u003cp data-path-to-node=\"11,4,0\"\u003eContraindicated in Type 1 diabetes, diabetic ketoacidosis, diabetic pre-coma\/coma, severe renal or hepatic insufficiency, concomitant treatment with miconazole, and during pregnancy or lactation.\u003c\/p\u003e\n\u003c\/li\u003e\n\u003c\/ul\u003e\n\u003ch2 data-path-to-node=\"13\"\u003e\u003cbr\u003e\u003c\/h2\u003e","brand":"Generic","offers":[{"title":"Default Title","offer_id":52232134394151,"sku":null,"price":2.08,"currency_code":"KWD","in_stock":true}],"thumbnail_url":"\/\/cdn.shopify.com\/s\/files\/1\/0708\/5044\/5607\/files\/iDiamicron_MR_60_mg_Modified-Release_30_Tablets.jpg?v=1792764199","url":"https:\/\/thetrustpharmacy.com\/en\/products\/diamicron-mr-60-mg-modified-release-30-tablets","provider":"Trust Pharmacy","version":"1.0","type":"link"}