Ciproxen 500 mg 10 Tab

Ciproxen 500 mg is an oral systemic antibacterial medication formulated with Ciprofloxacin Hydrochloride equivalent to 500 mg of ciprofloxacin base. Belonging to the second-generation fluoroquinolone class, it exerts potent concentration-dependent bactericidal activity by inhibiting bacterial type II topoisomerases: DNA gyrase (responsible for introducing negative supercoils into double-stranded DNA) and topoisomerase IV (essential for daughter chromosomal decatenation during replication). This dual inhibition disrupts DNA replication, transcription, repair, and recombination, triggering rapid cell death across a broad spectrum of Gram-negative pathogens and selected Gram-positive organisms. Packaged in a box containing 10 film-coated tablets, it is indicated for moderate-to-severe systemic, urinary, and gastrointestinal infections.

Key Benefits

• Potent Gram-Negative Bactericidal Action: Highly active against aerobic Gram-negative bacilli, including Escherichia coli, Klebsiella pneumoniae, Proteus mirabilis, Enterobacter, and Pseudomonas aeruginosa.

• High Tissue & Intracellular Penetration: Achieves high concentrations in renal parenchyma, urinary tract tissues, prostate, pulmonary secretions, bone, and peritoneal fluid that equal or exceed corresponding serum levels.

• Rapid Clinical Resolution: High oral bioavailability (approx. 70–80%) delivers therapeutic tissue saturation quickly, matching intravenous efficacy in suitable clinical cases.

• Broad Infection Coverage: Effective across complex lower respiratory tract, complicated genitourinary, abdominal, and enteric bacterial infections.

• Favorable Post-Antibiotic Effect (PAE): Exerts prolonged suppression of bacterial regrowth even after serum drug levels fall below the minimum inhibitory concentration (MIC).

Key Ingredients (per tablet)

• Ciprofloxacin Hydrochloride (equivalent to 500 mg ciprofloxacin base): Synthetic broad-spectrum fluoroquinolone antibacterial agent.

• Core & Film-Coating Excipients: Microcrystalline cellulose, maize starch, crospovidone, colloidal anhydrous silica, magnesium stearate, hypromellose (HPMC), titanium dioxide, and macrogol/polyethylene glycol.

Key Features

• Product Type: Oral Broad-Spectrum Fluoroquinolone Antibacterial (Prescription-Only Medication)

• Indications: Complicated and uncomplicated urinary tract infections (pyelonephritis, cystitis), acute bacterial prostatitis, infectious diarrhea and enteric fevers (Salmonella, Shigella, Campylobacter), intra-abdominal infections (in combination with antianaerobic coverage), lower respiratory exacerbations, and bone and joint infections

• Rapid gastrointestinal absorption with high urinary excretion

• Pack size: 10 film-coated tablets (1 blister strip × 10 tablets)

How to Use

• Take 1 tablet (500 mg) every 12 hours (twice daily) swallowed whole with a full glass of water, with or without food.

• Maintain adequate hydration throughout the day to avoid crystalluria.

• Chelation Window: Take at least 2 hours before or 6 hours after antacids, sucralfate, iron, calcium, zinc, or dairy products (milk/yogurt alone).

• Finish the full prescribed course (typically 5 to 14 days depending on the infection site).

• Avoid excessive exposure to direct sunlight or UV lamps during therapy due to photosensitivity risks.